lyogenixlabs.com · research use only
Printed: 18/04/2026
For Research Use Only — Not for Human Consumption
This product is strictly intended for in-vitro research and laboratory use by qualified researchers. It is not approved for human or veterinary therapeutic use, self-administration, or any clinical application.
HGH Fragment 176-191
Lipolytic Peptide Fragment
5 mg lyophilized powder + 2 mL sterile water
Overview
HGH Fragment 176-191 is a synthetic peptide representing the C-terminal portion of human growth hormone, specifically amino acids 176 through 191. This fragment was identified through systematic research that mapped the lipolytic (fat-burning) region of the full GH molecule to this specific 16-amino acid sequence.
Remarkably, this fragment retains the fat-metabolizing properties of growth hormone while being devoid of the growth-promoting effects mediated by GH receptor activation. This dissociation of lipolytic from growth effects makes HGH Fragment 176-191 a unique research tool for studying fat metabolism pathways independent of IGF-1 axis stimulation.
Chemical Profile
| Property | Details |
|---|---|
| Sequence | C-terminal fragment of hGH (amino acids 176-191) |
| Molecular Weight | ~1817.1 Da |
| Purity | ≥98% (HPLC verified) |
| Form | Lyophilized Powder |
| Appearance | White to off-white powder |
| Solubility | Sterile water, saline |
| Storage | 2°C – 8°C, protect from light |
Mechanism of Action
HGH Fragment 176-191 mimics the lipolytic action of growth hormone by interacting with adipocyte membranes in a manner that stimulates lipolysis (fat breakdown) and inhibits lipogenesis (fat synthesis). Unlike full-length GH, this fragment does not activate the GH receptor or stimulate IGF-1 production.
The fragment's mechanism involves stimulation of beta-3 adrenergic receptor-associated pathways and activation of hormone-sensitive lipase (HSL) in adipocytes, promoting triglyceride hydrolysis and free fatty acid release. Additionally, it inhibits fatty acid synthase and acetyl-CoA carboxylase, key enzymes in de novo lipogenesis.
Research Applications
- Lipolysis and fat metabolism research
- Adipocyte biology and lipid studies
- Anti-lipogenic mechanism research
- Cartilage repair and regeneration
- Body composition studies without IGF-1 effects
- Obesity and metabolic disorder models
Handling & Reconstitution
- 1Allow the vial and sterile water to reach room temperature (15–25°C).
- 2Using a sterile syringe, withdraw the appropriate volume of sterile water.
- 3Inject the water slowly along the inside wall of the vial — do not spray directly onto the powder.
- 4Gently swirl the vial until the powder is fully dissolved. Do not shake vigorously.
- 5Once reconstituted, store at 2°C – 8°C. Protect from light.
- 6Use within 28 days after reconstitution.
- 7Do not freeze reconstituted solution.
Product Specifications
- 1 × Vial (2R) containing HGH Fragment 176-191 lyophilized powder (5 mg)
- 1 × Ampoule Sterile Water for Injection (2 mL)
- Storage: 2°C – 8°C, protect from light
- Shelf life: 24 months (unopened, properly stored)
Ingredients
Human Growth Hormone Fragment 176-191 (5 mg), Mannitol, Sucrose
Certificate of Analysis
Full CoA with HPLC purity data and mass spectrometry confirmation is available for every batch.
Request CoARelated Products
Disclaimer
This product is intended for research and laboratory use only. Not for human consumption. LyoGenix Labs Pvt. Ltd. does not condone or promote the use of these compounds outside of legitimate research.
Authenticity Guarantee
Every LyoGenix product ships with a unique scratch code under a tamper-evident holographic label. Scratch the label to reveal your code and verify it here — confirming your product is genuine.
- Cryptographically unique code per box
- One-time verification — tracks first use
- Genuine LyoGenix Labs guarantee